Assay Detail
Binding
CHEMBL878393
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Compound was evaluated for its binding affinity with Dopamine receptor D2 using membranes prepared from rat striatum
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.61 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.43 |
| CHEMBL428175 | RWJ-25730 | — | 1 | 9.10 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.51 |
| CHEMBL59878 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL428175 | RWJ-25730 | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL85 | RISPERIDONE | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL59878 | — | Ki | = | 41.0 | nM | 7.39 |