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Assay Detail

CHEMBL878642

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration against Trypanosoma cruzi (amastigotes)
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Expert

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.
Szajnman SH, Montalvetti A, Wang Y, Docampo R, Rodriguez JB.
Bioorg Med Chem Lett (2003) 13 : 3231 -3235
PubMed 12951099 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.53 4.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL55264 2 4.74
CHEMBL52761 1 4.67
CHEMBL110971 1 4.18
CHEMBL109374 1 -
CHEMBL111695 1 -
CHEMBL299988 1 -
CHEMBL298547 1 -
CHEMBL113140 1 -
CHEMBL324003 1 -
CHEMBL55810 1 -
CHEMBL111531 1 -
CHEMBL322551 1 -
CHEMBL111129 1 -
CHEMBL111593 1 -
CHEMBL322081 1 -
CHEMBL112840 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL55264 IC50 = 18100.0 nM 4.74
CHEMBL52761 IC50 = 21400.0 nM 4.67
CHEMBL110971 IC50 = 65800.0 nM 4.18
CHEMBL109374 IC50 > 70000.0 nM -
CHEMBL111695 IC50 > 22360.0 nM -
CHEMBL299988 IC50 > 70000.0 nM -
CHEMBL55264 IC50 > 70000.0 nM -
CHEMBL298547 IC50 > 70000.0 nM -
CHEMBL324003 IC50 > 70000.0 nM -
CHEMBL55810 IC50 > 70000.0 nM -
CHEMBL111531 IC50 > 70000.0 nM -
CHEMBL322551 IC50 > 70000.0 nM -
CHEMBL111129 IC50 > 50000.0 nM -
CHEMBL111593 IC50 > 100000.0 nM -
CHEMBL322081 IC50 > 70000.0 nM -
CHEMBL112840 IC50 > 90000.0 nM -
CHEMBL113140 IC50 > 50000.0 nM -