Assay Detail
Functional
CHEMBL878666
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Optimal dose administered as a single dose by intraperitoneal inoculation of 10 X E6 murine leukemia P388 cell lines.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of DNA-targeted spatially separated bis(aniline mustards) as potential alkylating agents with enhanced DNA cross-linking capability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.36 | 4.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79723 | — | — | 1 | 4.88 |
| CHEMBL313191 | — | — | 1 | 4.35 |
| CHEMBL278918 | — | — | 1 | 4.19 |
| CHEMBL273595 | — | — | 1 | 4.19 |
| CHEMBL83806 | — | — | 1 | 4.19 |
| CHEMBL314685 | — | — | 1 | - |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79723 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL313191 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL278918 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL273595 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL83806 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL314685 | — | IC50 | = | - | nM | - |
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 225000.0 | nM | - |