Assay Detail
Functional
CHEMBL878682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.98 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421013 | — | — | 1 | 11.00 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 10.77 |
| CHEMBL34730 | — | — | 1 | 10.40 |
| CHEMBL95920 | — | — | 1 | 10.20 |
| CHEMBL99377 | — | — | 1 | 9.32 |
| CHEMBL330385 | — | — | 1 | 9.00 |
| CHEMBL99376 | — | — | 1 | 8.92 |
| CHEMBL95266 | — | — | 1 | 8.89 |
| CHEMBL53015 | — | — | 1 | 8.85 |
| CHEMBL316854 | — | — | 1 | 8.80 |
| CHEMBL95364 | — | — | 1 | 8.60 |
| CHEMBL52801 | — | — | 1 | 8.52 |
| CHEMBL95366 | — | — | 1 | 8.19 |
| CHEMBL95851 | — | — | 1 | 8.10 |
| CHEMBL421569 | — | — | 1 | 8.09 |
| CHEMBL99778 | — | — | 1 | 7.66 |
| CHEMBL322193 | — | — | 1 | 7.28 |
| CHEMBL289233 | IODOMELATONIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421013 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL45 | MELATONIN | IC50 | = | 0.017 | nM | 10.77 |
| CHEMBL34730 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL95920 | — | IC50 | = | 0.063 | nM | 10.20 |
| CHEMBL99377 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL330385 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL99376 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL95266 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL53015 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL316854 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL95364 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL52801 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL95366 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL95851 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL421569 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL99778 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL322193 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL289233 | IODOMELATONIN | IC50 | = | 0.005 | nM | - |