Assay Detail
Binding
CHEMBL879191
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Inhibitory activity against human thrombin
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 8.73 | 10.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281982 | — | — | 1 | 10.06 |
| CHEMBL26679 | — | — | 1 | 9.80 |
| CHEMBL29744 | — | — | 1 | 9.72 |
| CHEMBL25845 | — | — | 1 | 9.59 |
| CHEMBL418017 | — | — | 1 | 9.10 |
| CHEMBL29389 | — | — | 1 | 9.07 |
| CHEMBL28966 | — | — | 1 | 8.96 |
| CHEMBL26213 | — | — | 1 | 8.92 |
| CHEMBL285579 | — | — | 1 | 8.89 |
| CHEMBL284871 | — | — | 1 | 8.77 |
| CHEMBL286720 | — | — | 1 | 8.74 |
| CHEMBL416754 | — | — | 1 | 8.70 |
| CHEMBL282837 | — | — | 1 | 8.64 |
| CHEMBL29510 | — | — | 1 | 8.62 |
| CHEMBL29181 | — | — | 1 | 8.62 |
| CHEMBL26804 | — | — | 1 | 8.60 |
| CHEMBL29019 | — | — | 1 | 8.54 |
| CHEMBL29417 | — | — | 1 | 8.52 |
| CHEMBL27180 | — | — | 1 | 8.52 |
| CHEMBL29657 | — | — | 1 | 8.51 |
| CHEMBL28474 | — | — | 1 | 8.44 |
| CHEMBL284225 | — | — | 1 | 8.44 |
| CHEMBL29656 | — | — | 1 | 8.32 |
| CHEMBL30054 | DPOC-4088 | 1.0 | 1 | 8.28 |
| CHEMBL280640 | — | — | 1 | 8.28 |
| CHEMBL285796 | — | — | 1 | 8.20 |
| CHEMBL283851 | — | — | 1 | 8.15 |
| CHEMBL29592 | — | — | 1 | 8.15 |
| CHEMBL287417 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281982 | — | Ki | = | 0.087 | nM | 10.06 |
| CHEMBL26679 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL29744 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL25845 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL418017 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL29389 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL28966 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL26213 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL285579 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL284871 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL286720 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL416754 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL282837 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL29510 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL29181 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL26804 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL29019 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL29417 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL27180 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL29657 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL28474 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL284225 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL29656 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL30054 | DPOC-4088 | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL280640 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL285796 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL283851 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL29592 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL287417 | — | Ki | = | 7.3 | nM | 8.14 |