Assay Detail
Functional
CHEMBL879364
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Inhibition of Fyn-transformed rat fibroblast proliferation in anchorage independent assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.46 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122744 | — | — | 1 | 5.54 |
| CHEMBL440160 | — | — | 1 | 5.50 |
| CHEMBL354289 | — | — | 1 | 5.35 |
| CHEMBL166650 | — | — | 1 | - |
| CHEMBL101917 | — | — | 1 | - |
| CHEMBL349065 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122744 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL440160 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL354289 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL166650 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL101917 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL349065 | — | IC50 | > | 10000.0 | nM | - |