Assay Detail
Binding
CHEMBL879391
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Inhibition of bovine brain mitochondrial Monoamine oxidase A (MAO-A) compared to toloxatone
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.31 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18101 | (R/R)BEFLOXATONE | — | 1 | 8.60 |
| CHEMBL18334 | — | — | 1 | 8.31 |
| CHEMBL17653 | — | — | 1 | 7.05 |
| CHEMBL18019 | — | — | 1 | 6.70 |
| CHEMBL1794849 | — | — | 1 | 6.57 |
| CHEMBL18116 | TOLOXATONE | 4.0 | 1 | 6.42 |
| CHEMBL18390 | — | — | 1 | 6.00 |
| CHEMBL17562 | — | — | 1 | 5.92 |
| CHEMBL17643 | — | — | 1 | 5.92 |
| CHEMBL279544 | — | — | 1 | 5.60 |
| CHEMBL274947 | — | — | 1 | 4.40 |
| CHEMBL17981 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18101 | (R/R)BEFLOXATONE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL18334 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL17653 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL18019 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL1794849 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL18116 | TOLOXATONE | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL18390 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL17562 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL17643 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL279544 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL274947 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL17981 | — | Ki | = | 53000.0 | nM | 4.28 |