Assay Detail
Binding
CHEMBL879549
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and molecular modeling of 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 dopamine antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.76 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60706 | — | — | 1 | 6.54 |
| CHEMBL135318 | — | — | 1 | 6.54 |
| CHEMBL299056 | — | — | 1 | 6.28 |
| CHEMBL62 | SCH-23390 | — | 1 | 6.17 |
| CHEMBL334350 | — | — | 1 | 5.89 |
| CHEMBL303993 | — | — | 1 | 5.73 |
| CHEMBL300778 | — | — | 1 | 5.72 |
| CHEMBL57988 | — | — | 1 | 5.44 |
| CHEMBL293158 | — | — | 1 | 4.72 |
| CHEMBL446396 | — | — | 1 | 4.58 |
| CHEMBL434809 | — | — | 1 | - |
| CHEMBL137420 | — | — | 1 | - |
| CHEMBL109723 | — | — | 1 | - |
| CHEMBL323771 | — | — | 1 | - |
| CHEMBL445129 | — | — | 1 | - |
| CHEMBL336218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60706 | — | Ki | = | 287.0 | nM | 6.54 |
| CHEMBL135318 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL299056 | — | Ki | = | 522.0 | nM | 6.28 |
| CHEMBL62 | SCH-23390 | Ki | = | 676.0 | nM | 6.17 |
| CHEMBL334350 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL303993 | — | Ki | = | 1850.0 | nM | 5.73 |
| CHEMBL300778 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL57988 | — | Ki | = | 3620.0 | nM | 5.44 |
| CHEMBL293158 | — | Ki | = | 19200.0 | nM | 4.72 |
| CHEMBL446396 | — | Ki | = | 26300.0 | nM | 4.58 |
| CHEMBL434809 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL137420 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL109723 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL323771 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL445129 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL336218 | — | Ki | > | 3000.0 | nM | - |