Assay Detail
Binding
CHEMBL879552
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Binding affinity against Dopamine receptor D2 from rat brain, using [3H](-)-sulpiride as radioligand.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.72 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20377 | — | — | 1 | 5.95 |
| CHEMBL71049 | — | — | 1 | 5.88 |
| CHEMBL70807 | — | — | 1 | 5.54 |
| CHEMBL70861 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20377 | — | Ki | = | 1112.0 | nM | 5.95 |
| CHEMBL71049 | — | Ki | = | 1311.0 | nM | 5.88 |
| CHEMBL70807 | — | Ki | = | 2902.0 | nM | 5.54 |
| CHEMBL70861 | — | Ki | = | 3111.0 | nM | 5.51 |