Assay Detail
Functional
CHEMBL879758
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Delta or Mu antagonist activity tested in mouse vas deferens (MVD) along with N,N-dimethyl-Dmt-Tic-OH
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 9.73 | 9.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | — | 1 | 9.76 |
| CHEMBL109390 | — | — | 1 | 9.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | Kd | = | 0.1738 | nM | 9.76 |
| CHEMBL109390 | — | Kd | = | 0.1995 | nM | 9.70 |