Assay Detail
Binding
CHEMBL879867
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards Dopamine receptor D2 in rat striatum was determined using [3H]-spiperone as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Characterization of potent and selective antagonists at postsynaptic 5-HT1A receptors in a series of N4-substituted arylpiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.06 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13647 | BMY-7378 | — | 1 | 7.76 |
| CHEMBL131011 | — | — | 1 | 7.38 |
| CHEMBL130276 | — | — | 1 | 7.31 |
| CHEMBL49247 | — | — | 1 | 6.46 |
| CHEMBL38288 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13647 | BMY-7378 | Ki | = | 17.38 | nM | 7.76 |
| CHEMBL131011 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL130276 | — | Ki | = | 48.98 | nM | 7.31 |
| CHEMBL49247 | — | Ki | = | 346.74 | nM | 6.46 |
| CHEMBL38288 | — | Ki | = | 389.05 | nM | 6.41 |