Assay Detail
Functional
CHEMBL880087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro effective concentration required to agonise oxotremorine-induced tremors in guinea pig ileum.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.57 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310852 | — | — | 1 | 6.72 |
| CHEMBL169112 | — | — | 1 | 5.12 |
| CHEMBL354983 | — | — | 1 | 4.87 |
| CHEMBL169850 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310852 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL169112 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL354983 | — | EC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL169850 | — | EC50 | > | 500000.0 | nM | - |