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Assay Detail

CHEMBL880098

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of porcine gastric H+/K+ ATPase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Stomach
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Potassium-transporting ATPase (CHEMBL2095228)
Type PROTEIN COMPLEX
Organism Sus scrofa

Publication

Nicotinamide derivatives as a new class of gastric H+/K(+)-ATPase inhibitors. 1. Synthesis and structure-activity relationships of N-substituted 2-(benzhydryl- and benzylsulfinyl)nicotinamides.
Terauchi H, Tanitame A, Tada K, Nakamura K, Seto Y, Nishikawa Y.
J Med Chem (1997) 40 : 313 -321
PubMed 9022797 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.20 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL316658 1 6.72
CHEMBL323034 1 6.66
CHEMBL322088 1 6.28
CHEMBL108285 1 5.14
CHEMBL108610 1 -
CHEMBL108536 1 -
CHEMBL325803 1 -
CHEMBL322809 1 -
CHEMBL111282 1 -
CHEMBL432440 1 -
CHEMBL323189 1 -
CHEMBL110960 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL316658 IC50 = 190.0 nM 6.72
CHEMBL323034 IC50 = 220.0 nM 6.66
CHEMBL322088 IC50 = 530.0 nM 6.28
CHEMBL108285 IC50 = 7300.0 nM 5.14
CHEMBL108610 IC50 > 100000.0 nM -
CHEMBL108536 IC50 > 100000.0 nM -
CHEMBL325803 IC50 > 100000.0 nM -
CHEMBL322809 IC50 > 100000.0 nM -
CHEMBL111282 IC50 > 100000.0 nM -
CHEMBL432440 IC50 > 100000.0 nM -
CHEMBL323189 IC50 > 100000.0 nM -
CHEMBL110960 IC50 > 100000.0 nM -