Assay Detail
Binding
CHEMBL880437
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Inhibitory concentration against human dipeptidylpeptidase 9 using FP-TAMRA incubated for 30 min
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Boro-norleucine as a P1 residue for the design of selective and potent DPP7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.97 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195189 | — | — | 1 | 8.70 |
| CHEMBL194852 | — | — | 1 | 8.34 |
| CHEMBL194428 | — | — | 1 | 8.17 |
| CHEMBL194249 | — | — | 1 | 7.19 |
| CHEMBL196180 | — | — | 1 | 6.80 |
| CHEMBL195271 | — | — | 1 | 6.66 |
| CHEMBL194517 | — | — | 1 | 6.55 |
| CHEMBL373319 | — | — | 1 | 6.40 |
| CHEMBL194250 | — | — | 1 | 6.29 |
| CHEMBL194354 | — | — | 1 | 6.10 |
| CHEMBL365322 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195189 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL194852 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL194428 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL194249 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL196180 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL195271 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL194517 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL373319 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL194250 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL194354 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL365322 | — | IC50 | = | 3200.0 | nM | 5.50 |