Compound Detail
CHEMBL194852
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Basic Information
| ChEMBL ID | CHEMBL194852 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KYIRAKNWGLQGKF-DTWKUNHWSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
228.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 2 CHEMBL3976 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 8.35 | 8.35 | 4.5 | 1 |
| Dipeptidyl peptidase 9 CHEMBL4793 | IC50 | 8.34 | 8.34 | 4.6 | 1 |
| Dipeptidyl peptidase 8 CHEMBL4657 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
| Prolyl endopeptidase FAP CHEMBL4683 | IC50 | 5.39 | 5.39 | 4100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 2 | IC50 | = | 2.0 | nM | 8.7 | Inhibitory concentration against human dipeptidylpeptidase 7 | 16084722 |
| Dipeptidyl peptidase 4 | IC50 | = | 4.5 | nM | 8.35 | Inhibitory concentration against human dipeptidylpeptidase 4 | 16084722 |
| Dipeptidyl peptidase 9 | IC50 | = | 4.6 | nM | 8.34 | Inhibitory concentration against human dipeptidylpeptidase 9 using FP-TAMRA incu... | 16084722 |
| Dipeptidyl peptidase 8 | IC50 | = | 30.0 | nM | 7.52 | Inhibitory concentration against human dipeptidylpeptidase 8 using FP-TAMRA incu... | 16084722 |
| Prolyl endopeptidase FAP | IC50 | = | 4100.0 | nM | 5.39 | Inhibitory concentration against human fibroblast activation protein alpha | 16084722 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16084722 | 10.1016/j.bmcl.2005.06.076 | Dipeptidyl peptidase 2 | 1 |
| 16084722 | 10.1016/j.bmcl.2005.06.076 | Dipeptidyl peptidase 4 | 1 |
| 16084722 | 10.1016/j.bmcl.2005.06.076 | Prolyl endopeptidase FAP | 1 |
| 16084722 | 10.1016/j.bmcl.2005.06.076 | Dipeptidyl peptidase 8 | 1 |
| 16084722 | 10.1016/j.bmcl.2005.06.076 | Dipeptidyl peptidase 9 | 1 |
Data from ChEMBL 36 via Core Engine