Assay Detail
Binding
CHEMBL880567
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Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.40 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305170 | — | — | 1 | 9.52 |
| CHEMBL196120 | — | — | 1 | 9.10 |
| CHEMBL196933 | — | — | 1 | 8.11 |
| CHEMBL373269 | — | — | 1 | 8.10 |
| CHEMBL427012 | — | — | 1 | 7.92 |
| CHEMBL371429 | — | — | 1 | 7.60 |
| CHEMBL362922 | — | — | 1 | 7.60 |
| CHEMBL371130 | — | — | 1 | 7.57 |
| CHEMBL382974 | — | — | 1 | 7.57 |
| CHEMBL196267 | — | — | 1 | 7.24 |
| CHEMBL372180 | — | — | 1 | 7.21 |
| CHEMBL382980 | — | — | 1 | 7.12 |
| CHEMBL381200 | — | — | 1 | 6.89 |
| CHEMBL381444 | — | — | 1 | 6.25 |
| CHEMBL196188 | — | — | 1 | 5.80 |
| CHEMBL434184 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305170 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL196120 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL196933 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL373269 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL427012 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL371429 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL362922 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL371130 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL382974 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL196267 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL372180 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL382980 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL381200 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL381444 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL196188 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL434184 | — | IC50 | = | 16000.0 | nM | 4.80 |