Compound Detail
CHEMBL305170
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Basic Information
| ChEMBL ID | CHEMBL305170 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FKCMADOPPWWGNZ-JGVFFNPUSA-N |
4
Targets
7
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
214.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 9.52 | 7.58 | 0.3 | 2 |
| Prolyl endopeptidase FAP CHEMBL4683 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
| Dipeptidyl peptidase 2 CHEMBL3976 | IC50 | 7.68 | 7.55 | 21.0 | 2 |
| Prolyl endopeptidase CHEMBL3202 | IC50 | 4.21 | 4.21 | 61000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 | IC50 | = | 0.3 | nM | 9.52 | Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay | 16085416 |
| Prolyl endopeptidase FAP | IC50 | = | 11.0 | nM | 7.96 | Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay | 16085416 |
| Dipeptidyl peptidase 2 | IC50 | = | 21.0 | nM | 7.68 | Compound was tested in vitro for inhibition of Dipeptidylpeptidase II | 8642568 |
| Dipeptidyl peptidase 2 | IC50 | = | 38.0 | nM | 7.42 | Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay | 16085416 |
| Dipeptidyl peptidase 4 | IC50 | = | 2300.0 | nM | 5.64 | Inhibition of human placental DPP4 at pH 2 | 17458948 |
| Prolyl endopeptidase | IC50 | = | 61000.0 | nM | 4.21 | Compound was tested in vitro for inhibition of Prolyl endopeptidase | 8642568 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17458948 | 10.1021/jm061321+ | Dipeptidyl peptidase 4 | 2 |
| 8642568 | 10.1021/jm950732f | Dipeptidyl peptidase 4 | 1 |
| 8642568 | 10.1021/jm950732f | Dipeptidyl peptidase 2 | 1 |
| 8642568 | 10.1021/jm950732f | Prolyl endopeptidase | 1 |
| 16085416 | 10.1016/j.bmcl.2005.06.075 | Dipeptidyl peptidase 4 | 1 |
| 16085416 | 10.1016/j.bmcl.2005.06.075 | Prolyl endopeptidase FAP | 1 |
| 16085416 | 10.1016/j.bmcl.2005.06.075 | Dipeptidyl peptidase 2 | 1 |
Data from ChEMBL 36 via Core Engine