Assay Detail
Binding
CHEMBL884359
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Compound was tested in vitro for inhibition of Dipeptidylpeptidase II
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.62 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67279 | TALABOSTAT | 3.0 | 1 | 7.82 |
| CHEMBL305170 | — | — | 1 | 7.68 |
| CHEMBL63860 | — | — | 1 | 7.22 |
| CHEMBL1790478 | — | — | 1 | 6.14 |
| CHEMBL63895 | — | — | 1 | 6.11 |
| CHEMBL65406 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67279 | TALABOSTAT | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL305170 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL63860 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1790478 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL63895 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL65406 | — | IC50 | = | 18000.0 | nM | 4.75 |