Compound Detail
CHEMBL373269
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Basic Information
| ChEMBL ID | CHEMBL373269 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PDSFQJYJMMJUTN-MHCOZEDOSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
306.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prolyl endopeptidase FAP CHEMBL4683 | IC50 | 8.34 | 8.34 | 4.6 | 1 |
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 8.1 | 8.1 | 8.0 | 1 |
| Dipeptidyl peptidase 2 CHEMBL3976 | IC50 | 6.38 | 6.38 | 420.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prolyl endopeptidase FAP | IC50 | = | 4.6 | nM | 8.34 | Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay | 16085416 |
| Dipeptidyl peptidase 4 | IC50 | = | 8.0 | nM | 8.1 | Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay | 16085416 |
| Dipeptidyl peptidase 2 | IC50 | = | 420.0 | nM | 6.38 | Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay | 16085416 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16085416 | 10.1016/j.bmcl.2005.06.075 | Dipeptidyl peptidase 4 | 1 |
| 16085416 | 10.1016/j.bmcl.2005.06.075 | Prolyl endopeptidase FAP | 1 |
| 16085416 | 10.1016/j.bmcl.2005.06.075 | Dipeptidyl peptidase 2 | 1 |
Data from ChEMBL 36 via Core Engine