Assay Detail
Binding
CHEMBL880646
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Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of a novel series of N,N-dimethylisotryptamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 6.76 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138144 | — | — | 1 | 7.68 |
| CHEMBL336042 | — | — | 1 | 7.32 |
| CHEMBL137932 | — | — | 1 | 7.14 |
| CHEMBL344878 | — | — | 1 | 7.08 |
| CHEMBL336928 | — | — | 1 | 6.87 |
| CHEMBL139655 | — | — | 1 | 6.86 |
| CHEMBL137933 | — | — | 1 | 6.86 |
| CHEMBL422471 | — | — | 1 | 6.57 |
| CHEMBL138604 | — | — | 1 | 6.27 |
| CHEMBL138614 | — | — | 1 | 6.02 |
| CHEMBL344028 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138144 | — | Kd | = | 20.89 | nM | 7.68 |
| CHEMBL336042 | — | Kd | = | 47.86 | nM | 7.32 |
| CHEMBL137932 | — | Kd | = | 72.44 | nM | 7.14 |
| CHEMBL344878 | — | Kd | = | 83.18 | nM | 7.08 |
| CHEMBL336928 | — | Kd | = | 134.9 | nM | 6.87 |
| CHEMBL139655 | — | Kd | = | 138.04 | nM | 6.86 |
| CHEMBL137933 | — | Kd | = | 138.04 | nM | 6.86 |
| CHEMBL422471 | — | Kd | = | 269.15 | nM | 6.57 |
| CHEMBL138604 | — | Kd | = | 537.03 | nM | 6.27 |
| CHEMBL138614 | — | Kd | = | 954.99 | nM | 6.02 |
| CHEMBL344028 | — | Kd | = | 2089.3 | nM | 5.68 |