Assay Detail
Functional
CHEMBL880859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the contraction of New Zealand white rabbit saphenous vein
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Saphenous vein |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, biological activity and electrostatic properties of 3-[2-(dimethylamino)ethyl]-5-[(3-amino-1,2,4-thiadiazol-5-yl)methyl]-1H-indole, a novel 5-HT1D receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.83 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37462 | — | — | 1 | 8.00 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.80 |
| CHEMBL39243 | — | — | 1 | 6.30 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37462 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL39 | SEROTONIN | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL39243 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL128 | SUMATRIPTAN | EC50 | = | 630.96 | nM | 6.20 |