Assay Detail
Binding
CHEMBL881227
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against mouse dihydroorotate dehydrogenase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL2991) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.01 | 6.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 6.81 |
| CHEMBL154623 | — | — | 1 | 6.38 |
| CHEMBL193371 | — | — | 1 | 5.75 |
| CHEMBL157105 | — | — | 1 | 5.70 |
| CHEMBL348270 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL154623 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL193371 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL157105 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL348270 | — | IC50 | = | 4000.0 | nM | 5.40 |