Assay Detail
Binding
CHEMBL881277
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against adenosine A2A receptor of rat brain striatal membranes using [3H]CGS-21680
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.76 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413079 | — | — | 1 | 8.10 |
| CHEMBL136047 | — | — | 1 | 8.09 |
| CHEMBL344857 | — | — | 1 | 7.92 |
| CHEMBL138080 | — | — | 1 | 7.89 |
| CHEMBL138396 | — | — | 1 | 7.68 |
| CHEMBL138527 | — | — | 1 | 7.60 |
| CHEMBL343175 | — | — | 1 | 7.41 |
| CHEMBL139090 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413079 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL136047 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL344857 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL138080 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL138396 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL138527 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL343175 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL139090 | — | Ki | = | 42.0 | nM | 7.38 |