Assay Detail
Binding
CHEMBL882265
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Inhibition of [3H]- 5-HT uptake in Serotonin transporter using serotonin uptake assay in rat midbrain tissue
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Midbrain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.27 | 8.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14391 | — | — | 1 | 8.76 |
| CHEMBL306208 | — | — | 1 | 8.30 |
| CHEMBL82027 | — | — | 1 | 7.71 |
| CHEMBL340761 | — | — | 1 | 7.29 |
| CHEMBL2079586 | — | — | 1 | 7.00 |
| CHEMBL127040 | — | — | 1 | 6.89 |
| CHEMBL14144 | — | — | 1 | 6.41 |
| CHEMBL340912 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14391 | — | Ki | = | 1.74 | nM | 8.76 |
| CHEMBL306208 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL82027 | — | Ki | = | 19.38 | nM | 7.71 |
| CHEMBL340761 | — | Ki | = | 51.64 | nM | 7.29 |
| CHEMBL2079586 | — | Ki | = | 100.56 | nM | 7.00 |
| CHEMBL127040 | — | Ki | = | 128.62 | nM | 6.89 |
| CHEMBL14144 | — | Ki | = | 390.68 | nM | 6.41 |
| CHEMBL340912 | — | Ki | = | 1537.14 | nM | 5.81 |