Assay Detail
Binding
CHEMBL882391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]citalopram binding to the serotonin transporter in rhesus (Macaca mulatta) or cynomolgus monkey (Macaca fascicularis) caudate-putamen.
50
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Tissue | Caudate-putamen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 6.32 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87567 | — | — | 2 | 8.66 |
| CHEMBL87031 | — | — | 2 | 8.61 |
| CHEMBL86654 | — | — | 2 | 8.25 |
| CHEMBL91184 | — | — | 1 | 7.82 |
| CHEMBL330228 | — | — | 3 | 7.56 |
| CHEMBL315172 | — | — | 2 | 7.47 |
| CHEMBL86590 | — | — | 2 | 7.01 |
| CHEMBL84680 | — | — | 1 | 6.96 |
| CHEMBL2310846 | — | — | 2 | 6.86 |
| CHEMBL2079586 | — | — | 2 | 6.80 |
| CHEMBL421167 | — | — | 2 | 6.78 |
| CHEMBL316428 | — | — | 1 | 6.58 |
| CHEMBL2114227 | — | — | 1 | 6.54 |
| CHEMBL421546 | — | — | 1 | 6.17 |
| CHEMBL88915 | — | — | 1 | 6.06 |
| CHEMBL89476 | — | — | 1 | 6.00 |
| CHEMBL606929 | — | — | 1 | 5.91 |
| CHEMBL606928 | — | — | 1 | 5.80 |
| CHEMBL432571 | — | — | 1 | 5.48 |
| CHEMBL89906 | — | — | 1 | 5.31 |
| CHEMBL606930 | — | — | 1 | 5.27 |
| CHEMBL314887 | — | — | 2 | 5.24 |
| CHEMBL2115225 | — | — | 1 | 5.15 |
| CHEMBL89469 | — | — | 1 | 5.10 |
| CHEMBL314912 | — | — | 1 | 5.02 |
| CHEMBL88246 | — | — | 1 | 4.97 |
| CHEMBL89662 | — | — | 1 | 4.54 |
| CHEMBL89208 | — | — | 3 | 4.06 |
| CHEMBL89709 | — | — | 2 | - |
| CHEMBL330250 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87567 | — | IC50 | = | 2.19 | nM | 8.66 |
| CHEMBL87031 | — | IC50 | = | 2.47 | nM | 8.61 |
| CHEMBL86654 | — | IC50 | = | 5.57 | nM | 8.25 |
| CHEMBL87567 | — | IC50 | = | 5.95 | nM | 8.22 |
| CHEMBL91184 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL330228 | — | IC50 | = | 27.7 | nM | 7.56 |
| CHEMBL87031 | — | IC50 | = | 27.7 | nM | 7.56 |
| CHEMBL315172 | — | IC50 | = | 34.2 | nM | 7.47 |
| CHEMBL86654 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL86590 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL84680 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL2310846 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL2079586 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL421167 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL315172 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL316428 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2114227 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL330228 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL421546 | — | IC50 | = | 677.0 | nM | 6.17 |
| CHEMBL88915 | — | IC50 | = | 867.0 | nM | 6.06 |
| CHEMBL89476 | — | IC50 | = | 991.0 | nM | 6.00 |
| CHEMBL2079586 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL606929 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL330228 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL421167 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL606928 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL86590 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL432571 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL89906 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL2310846 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL606930 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL314887 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL2115225 | — | IC50 | = | 7038.0 | nM | 5.15 |
| CHEMBL89469 | — | IC50 | = | 7990.0 | nM | 5.10 |
| CHEMBL314912 | — | IC50 | = | 9560.0 | nM | 5.02 |
| CHEMBL88246 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL89662 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL89208 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL89709 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL314887 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL88563 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL89208 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL314138 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL88563 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL89754 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL86710 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL89756 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL89208 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL330250 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL89709 | — | IC50 | > | 20000.0 | nM | - |