Assay Detail
Binding
CHEMBL882467
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Inhibition constant against rat 5-hydroxytryptamine 2A receptor using [3H]ketanserin as radioligand with the compound (10 uM) dissolved in DMSO
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.86 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198124 | — | — | 1 | 6.70 |
| CHEMBL197664 | — | — | 1 | 6.23 |
| CHEMBL194588 | — | — | 1 | 6.08 |
| CHEMBL197646 | — | — | 1 | 6.00 |
| CHEMBL370859 | — | — | 1 | 5.77 |
| CHEMBL371899 | — | — | 1 | 5.16 |
| CHEMBL445331 | — | — | 1 | 5.08 |
| CHEMBL198123 | — | — | 1 | - |
| CHEMBL371753 | — | — | 1 | - |
| CHEMBL382750 | — | — | 1 | - |
| CHEMBL194203 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198124 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL197664 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL194588 | — | Ki | = | 834.0 | nM | 6.08 |
| CHEMBL197646 | — | Ki | = | 1008.0 | nM | 6.00 |
| CHEMBL370859 | — | Ki | = | 1683.0 | nM | 5.77 |
| CHEMBL371899 | — | Ki | = | 6903.0 | nM | 5.16 |
| CHEMBL445331 | — | Ki | = | 8367.0 | nM | 5.08 |
| CHEMBL198123 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL371753 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL382750 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL194203 | — | Ki | > | 10000.0 | nM | - |