Assay Detail
Binding
CHEMBL883660
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Binding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree C
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Angiotensin II pseudopeptides containing 1,3,5-trisubstituted benzene scaffolds with high AT2 receptor affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.78 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216061 | — | — | 1 | 9.80 |
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 9.02 |
| CHEMBL276163 | — | — | 1 | 7.52 |
| CHEMBL3350599 | — | — | 1 | - |
| CHEMBL196316 | — | — | 1 | - |
| CHEMBL3350600 | — | — | 1 | - |
| CHEMBL428986 | — | — | 1 | - |
| CHEMBL194864 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216061 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL408403 | ANGIOTENSIN II | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL276163 | — | Ki | = | 30.3 | nM | 7.52 |
| CHEMBL3350599 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL196316 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3350600 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL428986 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL194864 | — | Ki | > | 10000.0 | nM | - |