Assay Detail
Functional
CHEMBL883716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against human breast cancer T47D cell line inducing apoptosis activity was measured by cell and caspase-based HTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.32 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196832 | — | — | 1 | 7.72 |
| CHEMBL196453 | — | — | 1 | 6.80 |
| CHEMBL194831 | — | — | 1 | 6.48 |
| CHEMBL363844 | — | — | 1 | 6.32 |
| CHEMBL373137 | — | — | 1 | 6.14 |
| CHEMBL195026 | — | — | 1 | 5.96 |
| CHEMBL373355 | — | — | 1 | 5.92 |
| CHEMBL364032 | — | — | 1 | 5.24 |
| CHEMBL372090 | — | — | 1 | - |
| CHEMBL195911 | — | — | 1 | - |
| CHEMBL193401 | — | — | 1 | - |
| CHEMBL370885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196832 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL196453 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL194831 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL363844 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL373137 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL195026 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL373355 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL364032 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL372090 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL195911 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL193401 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL370885 | — | EC50 | > | 10000.0 | nM | - |