Assay Detail
Binding
CHEMBL884710
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Inhibition of 5-hydroxytryptamine reuptake
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New selective and potent 5-HT(1B/1D) antagonists: chemistry and pharmacological evaluation of N-piperazinylphenyl biphenylcarboxamides and biphenylsulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.75 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147503 | — | — | 1 | 6.39 |
| CHEMBL151420 | — | — | 1 | 6.05 |
| CHEMBL15928 | GR-127935 | — | 1 | 6.00 |
| CHEMBL443762 | — | — | 1 | 5.42 |
| CHEMBL359447 | — | — | 1 | 5.33 |
| CHEMBL281350 | SB-224289 | — | 1 | 5.33 |
| CHEMBL151894 | — | — | 1 | - |
| CHEMBL147071 | — | — | 1 | - |
| CHEMBL151695 | — | — | 1 | - |
| CHEMBL146735 | — | — | 1 | - |
| CHEMBL422504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147503 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL151420 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL15928 | GR-127935 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL443762 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL359447 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL281350 | SB-224289 | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL151894 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL147071 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL151695 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL146735 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL422504 | — | IC50 | > | 1000.0 | nM | - |