Assay Detail
Binding
CHEMBL884752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding inhibition towards human serotonin transporter
24
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 8.16 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 10.40 |
| CHEMBL196468 | — | — | 1 | 9.25 |
| CHEMBL197354 | — | — | 1 | 9.24 |
| CHEMBL198019 | — | — | 2 | 9.17 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 9.14 |
| CHEMBL199054 | — | — | 1 | 8.74 |
| CHEMBL180630 | — | — | 1 | 8.70 |
| CHEMBL361949 | — | — | 1 | 8.40 |
| CHEMBL373211 | — | — | 1 | 8.24 |
| CHEMBL199053 | — | — | 1 | 8.19 |
| CHEMBL1162965 | — | — | 1 | 8.15 |
| CHEMBL197966 | — | — | 1 | 8.13 |
| CHEMBL195774 | — | — | 1 | 8.05 |
| CHEMBL364050 | — | — | 1 | 8.00 |
| CHEMBL196513 | — | — | 2 | 7.85 |
| CHEMBL194910 | — | — | 1 | 7.77 |
| CHEMBL194960 | — | — | 1 | 7.42 |
| CHEMBL197315 | — | — | 1 | 7.39 |
| CHEMBL194909 | — | — | 1 | 7.23 |
| CHEMBL383347 | — | — | 1 | 7.00 |
| CHEMBL198018 | — | — | 2 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490 | PAROXETINE | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL196468 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL197354 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL198019 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL41 | FLUOXETINE | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL199054 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL180630 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL198019 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL361949 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL373211 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL199053 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL1162965 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL197966 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL195774 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL364050 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL196513 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL194910 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL196513 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL194960 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL197315 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL194909 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL383347 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL198018 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL198018 | — | Ki | = | 420.0 | nM | 6.38 |