Assay Detail
Binding
CHEMBL884947
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Negative logarithm causing 50% receptor occupancy against serotonin transporter
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Designed multiple ligands. An emerging drug discovery paradigm.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.34 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183460 | — | — | 1 | 8.20 |
| CHEMBL91418 | — | — | 1 | 7.50 |
| CHEMBL183921 | — | — | 1 | 7.30 |
| CHEMBL180700 | — | — | 1 | 7.10 |
| CHEMBL89245 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183460 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL91418 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL183921 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL180700 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL89245 | — | Ki | = | 251.19 | nM | 6.60 |