Assay Detail
Functional
CHEMBL885191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required for inhibition of necroptosis in FADD deficient Jurkat T cells treated with TNF-alpha
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationship study of novel necroptosis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 34 | 6.19 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370438 | — | — | 1 | 7.30 |
| CHEMBL363644 | — | — | 1 | 6.80 |
| CHEMBL382085 | — | — | 1 | 6.75 |
| CHEMBL370183 | — | — | 1 | 6.75 |
| CHEMBL381230 | — | — | 1 | 6.68 |
| CHEMBL365607 | — | — | 1 | 6.64 |
| CHEMBL370224 | — | — | 1 | 6.58 |
| CHEMBL382315 | — | — | 1 | 6.57 |
| CHEMBL197679 | — | — | 1 | 6.48 |
| CHEMBL198205 | — | — | 1 | 6.42 |
| CHEMBL195008 | NECROSTATIN | — | 1 | 6.31 |
| CHEMBL383605 | — | — | 1 | 6.23 |
| CHEMBL443568 | — | — | 1 | 6.20 |
| CHEMBL198336 | — | — | 1 | 6.15 |
| CHEMBL198101 | — | — | 1 | 6.07 |
| CHEMBL196317 | — | — | 1 | 5.89 |
| CHEMBL195951 | — | — | 1 | 5.42 |
| CHEMBL366165 | — | — | 1 | 5.32 |
| CHEMBL381646 | — | — | 1 | 5.25 |
| CHEMBL198653 | — | — | 1 | 5.24 |
| CHEMBL380816 | — | — | 1 | 5.04 |
| CHEMBL198337 | — | — | 1 | - |
| CHEMBL373282 | — | — | 1 | - |
| CHEMBL197939 | — | — | 1 | - |
| CHEMBL198156 | — | — | 1 | - |
| CHEMBL372959 | — | — | 1 | - |
| CHEMBL380818 | — | — | 1 | - |
| CHEMBL198657 | — | — | 1 | - |
| CHEMBL427189 | — | — | 1 | - |
| CHEMBL198830 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370438 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL363644 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL382085 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL370183 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL381230 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL365607 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL370224 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL382315 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL197679 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL198205 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL195008 | NECROSTATIN | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL383605 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL443568 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL198336 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL198101 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL196317 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL195951 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL366165 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL381646 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL198653 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL380816 | — | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL198337 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL373282 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL197939 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL198156 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL372959 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL380818 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL198657 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL427189 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL198830 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL194626 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL196046 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL366011 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL365948 | — | EC50 | > | 10000.0 | nM | - |