Assay Detail
Binding
CHEMBL885356
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Binding affinity against Alpha-1A adrenergic receptor from bovine clone
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.99 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324090 | ABANOQUIL | 2.0 | 1 | 10.52 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.77 |
| CHEMBL25554 | — | — | 1 | 9.46 |
| CHEMBL709 | ALFUZOSIN | 4.0 | 1 | 7.64 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324090 | ABANOQUIL | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL2 | PRAZOSIN | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL25554 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL709 | ALFUZOSIN | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL611 | TERAZOSIN | Ki | = | 26.0 | nM | 7.58 |