Assay Detail
Binding
CHEMBL885431
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Binding affinity at rat SERT
30
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 8.21 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233054 | — | — | 3 | 8.80 |
| CHEMBL394861 | — | — | 1 | 8.70 |
| CHEMBL395368 | — | — | 3 | 8.70 |
| CHEMBL246955 | — | — | 3 | 8.64 |
| CHEMBL246127 | — | — | 1 | 8.57 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.54 |
| CHEMBL246954 | — | — | 1 | 8.52 |
| CHEMBL397299 | — | — | 1 | 8.37 |
| CHEMBL246749 | — | — | 1 | 8.36 |
| CHEMBL233053 | — | — | 1 | 8.32 |
| CHEMBL395609 | — | — | 1 | 8.30 |
| CHEMBL246331 | — | — | 1 | 8.28 |
| CHEMBL247161 | — | — | 1 | 8.22 |
| CHEMBL246748 | — | — | 1 | 8.11 |
| CHEMBL246540 | — | — | 1 | 8.08 |
| CHEMBL397065 | — | — | 1 | 7.89 |
| CHEMBL246542 | — | — | 1 | 7.85 |
| CHEMBL397300 | — | — | 1 | 7.85 |
| CHEMBL246332 | — | — | 1 | 7.80 |
| CHEMBL246333 | — | — | 1 | 7.77 |
| CHEMBL395608 | — | — | 1 | 7.66 |
| CHEMBL246747 | — | — | 1 | 7.52 |
| CHEMBL246953 | — | — | 1 | 7.44 |
| CHEMBL246541 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233054 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL233054 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL394861 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL395368 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL395368 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL246955 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL246127 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL41 | FLUOXETINE | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL246955 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL246954 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL246955 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL397299 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL246749 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL233054 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL233053 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL395368 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL395609 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL246331 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL247161 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL246748 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL246540 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL397065 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL397300 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL246542 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL246332 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL246333 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL395608 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL246747 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL246953 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL246541 | — | Ki | = | 120.0 | nM | 6.92 |