Assay Detail
Binding
CHEMBL886505
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membrane
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 6.63 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392798 | — | — | 1 | 8.29 |
| CHEMBL393781 | — | — | 1 | 7.96 |
| CHEMBL284414 | — | — | 1 | 7.72 |
| CHEMBL391082 | — | — | 1 | 7.66 |
| CHEMBL240215 | — | — | 1 | 7.53 |
| CHEMBL428033 | — | — | 1 | 7.52 |
| CHEMBL401451 | — | — | 1 | 7.43 |
| CHEMBL239822 | — | — | 1 | 7.32 |
| CHEMBL393807 | — | — | 1 | 7.31 |
| CHEMBL241087 | — | — | 1 | 7.23 |
| CHEMBL240005 | — | — | 1 | 7.14 |
| CHEMBL392893 | — | — | 1 | 7.13 |
| CHEMBL239824 | — | — | 1 | 6.88 |
| CHEMBL241086 | — | — | 1 | 6.88 |
| CHEMBL240033 | — | — | 1 | 6.88 |
| CHEMBL241085 | — | — | 1 | 6.79 |
| CHEMBL240896 | — | — | 1 | 6.63 |
| CHEMBL241112 | — | — | 1 | 6.61 |
| CHEMBL27460 | — | — | 1 | 6.46 |
| CHEMBL439212 | — | — | 1 | 6.46 |
| CHEMBL240216 | — | — | 1 | 6.45 |
| CHEMBL391083 | — | — | 1 | 6.40 |
| CHEMBL241067 | — | — | 1 | 6.32 |
| CHEMBL240657 | — | — | 1 | 6.31 |
| CHEMBL203356 | — | — | 1 | 6.30 |
| CHEMBL239820 | — | — | 1 | 6.25 |
| CHEMBL241272 | — | — | 1 | 6.22 |
| CHEMBL442090 | — | — | 1 | 6.17 |
| CHEMBL428563 | — | — | 1 | 6.11 |
| CHEMBL391703 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392798 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL393781 | — | Ki | = | 11.1 | nM | 7.96 |
| CHEMBL284414 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL391082 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL240215 | — | Ki | = | 29.5 | nM | 7.53 |
| CHEMBL428033 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL401451 | — | Ki | = | 37.4 | nM | 7.43 |
| CHEMBL239822 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL393807 | — | Ki | = | 49.1 | nM | 7.31 |
| CHEMBL241087 | — | Ki | = | 59.1 | nM | 7.23 |
| CHEMBL240005 | — | Ki | = | 72.3 | nM | 7.14 |
| CHEMBL392893 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL239824 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL241086 | — | Ki | = | 130.5 | nM | 6.88 |
| CHEMBL240033 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL241085 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL240896 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL241112 | — | Ki | = | 244.0 | nM | 6.61 |
| CHEMBL27460 | — | Ki | = | 346.0 | nM | 6.46 |
| CHEMBL439212 | — | Ki | = | 346.0 | nM | 6.46 |
| CHEMBL240216 | — | Ki | = | 355.0 | nM | 6.45 |
| CHEMBL391083 | — | Ki | = | 398.0 | nM | 6.40 |
| CHEMBL241067 | — | Ki | = | 475.0 | nM | 6.32 |
| CHEMBL240657 | — | Ki | = | 486.0 | nM | 6.31 |
| CHEMBL203356 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL239820 | — | Ki | = | 567.0 | nM | 6.25 |
| CHEMBL241272 | — | Ki | = | 595.0 | nM | 6.22 |
| CHEMBL442090 | — | Ki | = | 673.0 | nM | 6.17 |
| CHEMBL428563 | — | Ki | = | 778.0 | nM | 6.11 |
| CHEMBL391703 | — | Ki | = | 787.0 | nM | 6.10 |
| CHEMBL392969 | — | Ki | = | 818.0 | nM | 6.09 |
| CHEMBL240001 | — | Ki | = | 887.0 | nM | 6.05 |
| CHEMBL393980 | — | Ki | = | 977.0 | nM | 6.01 |
| CHEMBL241079 | — | Ki | = | 1109.0 | nM | 5.96 |
| CHEMBL239819 | — | Ki | = | 1616.0 | nM | 5.79 |
| CHEMBL240895 | — | Ki | = | 1761.0 | nM | 5.75 |
| CHEMBL240870 | — | Ki | = | 2454.0 | nM | 5.61 |
| CHEMBL239821 | — | Ki | = | 3187.0 | nM | 5.50 |
| CHEMBL241080 | — | Ki | = | 5081.0 | nM | 5.29 |
| CHEMBL240869 | — | Ki | - | — | - | |
| CHEMBL240897 | — | Ki | - | — | - |