Assay Detail
Binding
CHEMBL886654
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Binding affinity to rat SERT
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.23 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.54 |
| CHEMBL247670 | — | — | 1 | 7.82 |
| CHEMBL247683 | — | — | 1 | 7.82 |
| CHEMBL247265 | — | — | 1 | 7.82 |
| CHEMBL247669 | — | — | 1 | 7.75 |
| CHEMBL247267 | — | — | 1 | 7.72 |
| CHEMBL394732 | — | — | 1 | 7.70 |
| CHEMBL246874 | — | — | 1 | 7.66 |
| CHEMBL392933 | — | — | 1 | 7.64 |
| CHEMBL247094 | — | — | 1 | 7.58 |
| CHEMBL247472 | — | — | 1 | 7.54 |
| CHEMBL246873 | — | — | 1 | 7.52 |
| CHEMBL236252 | — | — | 1 | 7.48 |
| CHEMBL238052 | — | — | 1 | 7.47 |
| CHEMBL247671 | — | — | 1 | 7.35 |
| CHEMBL241706 | — | — | 1 | 7.34 |
| CHEMBL247470 | — | — | 1 | 7.28 |
| CHEMBL241705 | — | — | 1 | 7.23 |
| CHEMBL247266 | — | — | 1 | 6.89 |
| CHEMBL392429 | — | — | 1 | 6.84 |
| CHEMBL241712 | — | — | 1 | 6.73 |
| CHEMBL247063 | — | — | 1 | 6.72 |
| CHEMBL247076 | — | — | 1 | 6.71 |
| CHEMBL247061 | — | — | 1 | 6.25 |
| CHEMBL247268 | — | — | 1 | 6.23 |
| CHEMBL247062 | — | — | 1 | 5.78 |
| CHEMBL391605 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41 | FLUOXETINE | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL247670 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL247683 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL247265 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL247669 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL247267 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL394732 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL246874 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL392933 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL247094 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL247472 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL246873 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL236252 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL238052 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL247671 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL241706 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL247470 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL241705 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL247266 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL392429 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL241712 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL247063 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL247076 | — | Ki | = | 194.0 | nM | 6.71 |
| CHEMBL247061 | — | Ki | = | 569.0 | nM | 6.25 |
| CHEMBL247268 | — | Ki | = | 583.0 | nM | 6.23 |
| CHEMBL247062 | — | Ki | = | 1667.0 | nM | 5.78 |
| CHEMBL391605 | — | Ki | = | 2000.0 | nM | 5.70 |