Assay Detail
Binding
CHEMBL886655
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Binding affinity to human SERT
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.78 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.66 |
| CHEMBL247265 | — | — | 1 | 7.58 |
| CHEMBL236252 | — | — | 1 | 7.52 |
| CHEMBL392933 | — | — | 1 | 7.51 |
| CHEMBL394732 | — | — | 1 | 7.50 |
| CHEMBL247669 | — | — | 1 | 7.43 |
| CHEMBL247671 | — | — | 1 | 7.21 |
| CHEMBL247267 | — | — | 1 | 7.18 |
| CHEMBL247472 | — | — | 1 | 7.16 |
| CHEMBL247670 | — | — | 1 | 7.03 |
| CHEMBL246874 | — | — | 1 | 6.97 |
| CHEMBL238052 | — | — | 1 | 6.97 |
| CHEMBL247683 | — | — | 1 | 6.92 |
| CHEMBL246873 | — | — | 1 | 6.85 |
| CHEMBL241706 | — | — | 1 | 6.83 |
| CHEMBL247094 | — | — | 1 | 6.83 |
| CHEMBL247470 | — | — | 1 | 6.72 |
| CHEMBL247266 | — | — | 1 | 6.65 |
| CHEMBL241705 | — | — | 1 | 6.52 |
| CHEMBL241712 | — | — | 1 | 6.44 |
| CHEMBL247063 | — | — | 1 | 6.12 |
| CHEMBL392429 | — | — | 1 | 6.08 |
| CHEMBL247061 | — | — | 1 | 5.94 |
| CHEMBL247076 | — | — | 1 | 5.88 |
| CHEMBL247268 | — | — | 1 | 5.70 |
| CHEMBL247062 | — | — | 1 | 5.63 |
| CHEMBL391605 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41 | FLUOXETINE | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL247265 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL236252 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL392933 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL394732 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL247669 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL247671 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL247267 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL247472 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL247670 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL246874 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL238052 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL247683 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL246873 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL241706 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL247094 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL247470 | — | Ki | = | 189.0 | nM | 6.72 |
| CHEMBL247266 | — | Ki | = | 226.0 | nM | 6.65 |
| CHEMBL241705 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL241712 | — | Ki | = | 362.0 | nM | 6.44 |
| CHEMBL247063 | — | Ki | = | 768.0 | nM | 6.12 |
| CHEMBL392429 | — | Ki | = | 826.0 | nM | 6.08 |
| CHEMBL247061 | — | Ki | = | 1137.0 | nM | 5.94 |
| CHEMBL247076 | — | Ki | = | 1333.0 | nM | 5.88 |
| CHEMBL247268 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL247062 | — | Ki | = | 2333.0 | nM | 5.63 |
| CHEMBL391605 | — | Ki | = | 4767.0 | nM | 5.32 |