Assay Detail
Functional
CHEMBL887072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human cloned mu opioid receptor assessed as stimulation of [35S]GTPgammaS binding
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Further studies of tyrosine surrogates in opioid receptor peptide ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.62 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247758 | — | — | 1 | 7.31 |
| CHEMBL391580 | — | — | 1 | 6.85 |
| CHEMBL246739 | — | — | 1 | 6.75 |
| CHEMBL247760 | — | — | 1 | 6.60 |
| CHEMBL246956 | — | — | 1 | 6.57 |
| CHEMBL246572 | — | — | 1 | 6.46 |
| CHEMBL13786 | — | — | 1 | 6.21 |
| CHEMBL247368 | — | — | 1 | 6.20 |
| CHEMBL246479 | — | — | 1 | - |
| CHEMBL31421 | — | — | 1 | - |
| CHEMBL2372104 | — | — | 1 | - |
| CHEMBL247363 | — | — | 1 | - |
| CHEMBL247163 | — | — | 1 | - |
| CHEMBL247562 | — | — | 1 | - |
| CHEMBL246682 | — | — | 1 | - |
| CHEMBL393867 | — | — | 1 | - |
| CHEMBL247064 | — | — | 1 | - |
| CHEMBL395863 | — | — | 1 | - |
| CHEMBL392275 | — | — | 1 | - |
| CHEMBL246740 | — | — | 1 | - |
| CHEMBL247759 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247758 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL391580 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL246739 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL247760 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL246956 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL246572 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL13786 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL247368 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL246479 | — | EC50 | - | — | - | |
| CHEMBL31421 | — | EC50 | - | — | - | |
| CHEMBL2372104 | — | EC50 | - | — | - | |
| CHEMBL247363 | — | EC50 | - | — | - | |
| CHEMBL247163 | — | EC50 | - | — | - | |
| CHEMBL247562 | — | EC50 | - | — | - | |
| CHEMBL246682 | — | EC50 | - | — | - | |
| CHEMBL393867 | — | EC50 | - | — | - | |
| CHEMBL247064 | — | EC50 | - | — | - | |
| CHEMBL395863 | — | EC50 | - | — | - | |
| CHEMBL392275 | — | EC50 | - | — | - | |
| CHEMBL246740 | — | EC50 | - | — | - | |
| CHEMBL247759 | — | EC50 | - | — | - |