Assay Detail
ADMET
CHEMBL887253
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Cytotoxicity against rat L6 cells by alamar blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.74 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228368 | — | — | 1 | 8.96 |
| CHEMBL228637 | — | — | 1 | 8.60 |
| CHEMBL231386 | — | — | 1 | 8.37 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.19 |
| CHEMBL231385 | — | — | 1 | 7.80 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.33 |
| CHEMBL397654 | — | — | 1 | 7.26 |
| CHEMBL231285 | — | — | 1 | 7.16 |
| CHEMBL231082 | — | — | 1 | 7.00 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228368 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL228637 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL231386 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL231385 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 46.6 | nM | 7.33 |
| CHEMBL397654 | — | IC50 | = | 54.3 | nM | 7.26 |
| CHEMBL231285 | — | IC50 | = | 69.4 | nM | 7.16 |
| CHEMBL231082 | — | IC50 | = | 100.3 | nM | 7.00 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 188.5 | nM | 6.72 |