Assay Detail
Binding
CHEMBL887272
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Inhibition of IGF1R
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.26 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231307 | — | — | 1 | 6.85 |
| CHEMBL389605 | — | — | 1 | 6.85 |
| CHEMBL390198 | — | — | 1 | 6.82 |
| CHEMBL231212 | — | — | 1 | 6.80 |
| CHEMBL231306 | — | — | 1 | 6.75 |
| CHEMBL387610 | — | — | 1 | 6.72 |
| CHEMBL231407 | — | — | 1 | 6.62 |
| CHEMBL387824 | — | — | 1 | 6.60 |
| CHEMBL388206 | — | — | 1 | 6.52 |
| CHEMBL230902 | — | — | 1 | 6.47 |
| CHEMBL231004 | — | — | 1 | 6.46 |
| CHEMBL231112 | — | — | 1 | 6.33 |
| CHEMBL231305 | — | — | 1 | 6.28 |
| CHEMBL231110 | — | — | 1 | 6.28 |
| CHEMBL231002 | — | — | 1 | 6.28 |
| CHEMBL231003 | — | — | 1 | 6.15 |
| CHEMBL396727 | — | — | 1 | 6.14 |
| CHEMBL231311 | — | — | 1 | 6.10 |
| CHEMBL387794 | — | — | 1 | 6.10 |
| CHEMBL425303 | — | — | 1 | 6.08 |
| CHEMBL387823 | — | — | 1 | 5.92 |
| CHEMBL269747 | — | — | 1 | 5.80 |
| CHEMBL263800 | — | — | 1 | 5.52 |
| CHEMBL410158 | — | — | 1 | 5.52 |
| CHEMBL396482 | — | — | 1 | 5.46 |
| CHEMBL231213 | — | — | 1 | 5.44 |
| CHEMBL425995 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231307 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL389605 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL390198 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL231212 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL231306 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL387610 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL231407 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL387824 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL388206 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL230902 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL231004 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL231112 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL231305 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL231110 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL231002 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL231003 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL396727 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL231311 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL387794 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL425303 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL387823 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL269747 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL263800 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL410158 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL396482 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL231213 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL425995 | — | IC50 | > | 25000.0 | nM | - |