Compound Detail
CHEMBL231003
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COc1cccc(C(O)CNc2cc[nH]c(=O)c2-c2nc3c(C)cc(-n4ccnc4)cc3[nH]2)c1
Basic Information
| ChEMBL ID | CHEMBL231003 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PQCIBFPSJBDHRR-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
456.5
MW (Da)
3.57
ALogP
7
HBA
4
HBD
120.8
PSA (Ų)
0.30
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 6.15 | 6.13 | 710.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 710.0 | nM | 6.15 | Inhibition of IGF1R | 17187980 |
| Insulin-like growth factor 1 receptor | IC50 | = | 780.0 | nM | 6.11 | Inhibition of IGF1R expressed in Sal cells | 17187980 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17187980 | 10.1016/j.bmcl.2006.11.041 | Insulin-like growth factor 1 receptor | 2 |
Data from ChEMBL 36 via Core Engine