Assay Detail
Functional
CHEMBL887273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IGF1R expressed in Sal cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Sal |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.14 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389605 | — | — | 1 | 6.72 |
| CHEMBL231306 | — | — | 1 | 6.43 |
| CHEMBL230902 | — | — | 1 | 6.38 |
| CHEMBL425303 | — | — | 1 | 6.36 |
| CHEMBL231305 | — | — | 1 | 6.33 |
| CHEMBL390198 | — | — | 1 | 6.27 |
| CHEMBL231110 | — | — | 1 | 6.21 |
| CHEMBL231212 | — | — | 1 | 6.12 |
| CHEMBL231004 | — | — | 1 | 6.12 |
| CHEMBL231003 | — | — | 1 | 6.11 |
| CHEMBL231002 | — | — | 1 | 6.11 |
| CHEMBL231112 | — | — | 1 | 5.90 |
| CHEMBL231407 | — | — | 1 | 5.79 |
| CHEMBL231311 | — | — | 1 | 5.75 |
| CHEMBL388206 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389605 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL231306 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL230902 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL425303 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL231305 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL390198 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL231110 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL231212 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL231004 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL231003 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL231002 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL231112 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL231407 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL231311 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL388206 | — | IC50 | = | 3630.0 | nM | 5.44 |