Assay Detail
Binding
CHEMBL887348
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Displacement of [3H]ketanserin from rat cloned 5HT2A receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.78 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388620 | — | — | 1 | 7.38 |
| CHEMBL228972 | — | — | 1 | 7.36 |
| CHEMBL229024 | — | — | 1 | 7.30 |
| CHEMBL229023 | — | — | 1 | 6.96 |
| CHEMBL388396 | — | — | 1 | 6.68 |
| CHEMBL229025 | — | — | 1 | 6.67 |
| CHEMBL387951 | — | — | 1 | 6.64 |
| CHEMBL228865 | — | — | 1 | 6.61 |
| CHEMBL228866 | — | — | 1 | 6.41 |
| CHEMBL387952 | — | — | 1 | 6.31 |
| CHEMBL229021 | — | — | 1 | 6.26 |
| CHEMBL229019 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388620 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL228972 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL229024 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL229023 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL388396 | — | Ki | = | 211.0 | nM | 6.68 |
| CHEMBL229025 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL387951 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL228865 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL228866 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL387952 | — | Ki | = | 487.0 | nM | 6.31 |
| CHEMBL229021 | — | Ki | = | 543.0 | nM | 6.26 |
| CHEMBL229019 | — | Ki | > | 1000.0 | nM | - |