Assay Detail
Binding
CHEMBL887388
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Displacement of [3H]DAMGO from human mu opioid receptors expressed in CHO cell membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
High-affinity carbamate analogues of morphinan at opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 9.26 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | — | 1 | 10.21 |
| CHEMBL397035 | — | — | 1 | 9.96 |
| CHEMBL242048 | — | — | 1 | 9.92 |
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | 9.68 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 9.64 |
| CHEMBL427862 | — | — | 1 | 9.54 |
| CHEMBL263096 | — | — | 1 | 9.52 |
| CHEMBL394624 | — | — | 1 | 9.15 |
| CHEMBL242046 | — | — | 1 | 8.92 |
| CHEMBL245049 | — | — | 1 | 8.85 |
| CHEMBL242047 | — | — | 1 | 8.43 |
| CHEMBL241823 | — | — | 1 | 8.32 |
| CHEMBL241824 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL397035 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL242048 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL592 | LEVORPHANOL | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL301160 | BUTORPHAN | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL427862 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL263096 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL394624 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL242046 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL245049 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL242047 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL241823 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL241824 | — | Ki | = | 5.3 | nM | 8.28 |