Assay Detail
Functional
CHEMBL887414
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human AR
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 7.81 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398226 | — | — | 1 | 9.22 |
| CHEMBL229264 | — | — | 1 | 9.15 |
| CHEMBL394592 | — | — | 1 | 9.00 |
| CHEMBL389607 | — | — | 1 | 8.77 |
| CHEMBL231122 | — | — | 1 | 8.77 |
| CHEMBL390849 | — | — | 1 | 8.77 |
| CHEMBL231014 | — | — | 1 | 8.66 |
| CHEMBL425646 | — | — | 1 | 8.64 |
| CHEMBL230052 | — | — | 1 | 8.55 |
| CHEMBL230694 | — | — | 1 | 8.44 |
| CHEMBL397274 | — | — | 1 | 8.21 |
| CHEMBL397217 | — | — | 1 | 7.44 |
| CHEMBL231015 | — | — | 1 | 7.33 |
| CHEMBL389606 | — | — | 1 | 7.28 |
| CHEMBL231328 | — | — | 1 | 7.10 |
| CHEMBL439873 | — | — | 1 | 7.01 |
| CHEMBL395502 | — | — | 1 | 6.66 |
| CHEMBL230053 | — | — | 1 | 6.46 |
| CHEMBL230695 | — | — | 1 | 6.31 |
| CHEMBL394593 | — | — | 1 | 6.22 |
| CHEMBL231327 | — | — | 1 | 5.97 |
| CHEMBL231121 | — | — | 1 | - |
| CHEMBL389805 | — | — | 1 | - |
| CHEMBL230594 | — | — | 1 | - |
| CHEMBL388421 | — | — | 1 | - |
| CHEMBL388210 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398226 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL229264 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL394592 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL389607 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL231122 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL390849 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL231014 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL425646 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL230052 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL230694 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL397274 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL397217 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL231015 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL389606 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL231328 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL439873 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL395502 | — | EC50 | = | 221.0 | nM | 6.66 |
| CHEMBL230053 | — | EC50 | = | 345.0 | nM | 6.46 |
| CHEMBL230695 | — | EC50 | = | 487.0 | nM | 6.31 |
| CHEMBL394593 | — | EC50 | = | 607.0 | nM | 6.22 |
| CHEMBL231327 | — | EC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL231121 | — | EC50 | - | — | - | |
| CHEMBL389805 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL230594 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL388421 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL388210 | — | EC50 | > | 10000.0 | nM | - |