Assay Detail
ADMET
CHEMBL887756
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Inhibition of CYP2D6 in microsomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Subcellular | Microsomes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.75 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230204 | — | — | 1 | 6.25 |
| CHEMBL397666 | — | — | 1 | 5.24 |
| CHEMBL440964 | — | — | 1 | - |
| CHEMBL230308 | — | — | 1 | - |
| CHEMBL230205 | — | — | 1 | - |
| CHEMBL397667 | — | — | 1 | - |
| CHEMBL231306 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230204 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL397666 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL440964 | — | IC50 | - | — | - | |
| CHEMBL230308 | — | IC50 | - | — | - | |
| CHEMBL230205 | — | IC50 | - | — | - | |
| CHEMBL397667 | — | IC50 | - | — | - | |
| CHEMBL231306 | — | IC50 | - | — | - |