Assay Detail
Binding
CHEMBL887786
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Binding affinity to NMDA NR2B receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2B (CHEMBL1904) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.06 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429656 | — | — | 1 | 8.70 |
| CHEMBL393670 | — | — | 1 | 8.66 |
| CHEMBL247323 | — | — | 1 | 8.44 |
| CHEMBL247718 | — | — | 1 | 8.10 |
| CHEMBL429475 | — | — | 1 | 7.18 |
| CHEMBL159279 | — | — | 1 | 7.14 |
| CHEMBL397784 | — | — | 1 | 7.12 |
| CHEMBL247113 | — | — | 1 | 6.65 |
| CHEMBL247717 | — | — | 1 | 6.53 |
| CHEMBL247114 | — | — | 1 | 6.45 |
| CHEMBL247115 | — | — | 1 | 6.30 |
| CHEMBL391389 | — | — | 1 | 5.38 |
| CHEMBL247716 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429656 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL393670 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL247323 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL247718 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL429475 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL159279 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL397784 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL247113 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL247717 | — | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL247114 | — | Ki | = | 353.0 | nM | 6.45 |
| CHEMBL247115 | — | Ki | = | 505.0 | nM | 6.30 |
| CHEMBL391389 | — | Ki | = | 4197.0 | nM | 5.38 |
| CHEMBL247716 | — | Ki | = | 7350.0 | nM | 5.13 |