Assay Detail
ADMET
CHEMBL889492
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human Jurkat T cells after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumour activity of new tiazofurin analogues bearing a 2,3-anhydro functionality in the furanose ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.56 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108358 | TIAZOFURIN | 2.0 | 1 | 6.29 |
| CHEMBL388924 | — | — | 1 | 5.66 |
| CHEMBL390900 | — | — | 1 | 5.32 |
| CHEMBL388925 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108358 | TIAZOFURIN | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL388924 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL390900 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL388925 | — | IC50 | = | 11010.0 | nM | 4.96 |