Assay Detail
ADMET
CHEMBL889923
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP2C9
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.04 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395542 | — | — | 1 | 5.30 |
| CHEMBL233245 | — | — | 1 | 5.27 |
| CHEMBL389796 | — | — | 1 | 5.05 |
| CHEMBL389996 | — | — | 1 | 4.92 |
| CHEMBL234940 | — | — | 1 | 4.85 |
| CHEMBL233043 | — | — | 1 | 4.85 |
| CHEMBL234290 | — | — | 1 | - |
| CHEMBL234939 | — | — | 1 | - |
| CHEMBL389994 | — | — | 1 | - |
| CHEMBL233044 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395542 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL233245 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL389796 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL389996 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL234940 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL233043 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL234290 | — | IC50 | - | — | - | |
| CHEMBL234939 | — | IC50 | - | — | - | |
| CHEMBL389994 | — | IC50 | - | — | - | |
| CHEMBL233044 | — | IC50 | - | — | - |