Assay Detail
Binding
CHEMBL890059
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Binding affinity to rat SERT
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 8.36 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396945 | — | — | 1 | 9.14 |
| CHEMBL234526 | — | — | 1 | 9.00 |
| CHEMBL394787 | — | — | 1 | 8.89 |
| CHEMBL394800 | — | — | 1 | 8.85 |
| CHEMBL396459 | — | — | 1 | 8.82 |
| CHEMBL233054 | — | — | 1 | 8.80 |
| CHEMBL394861 | — | — | 1 | 8.70 |
| CHEMBL233471 | — | — | 1 | 8.70 |
| CHEMBL396703 | — | — | 1 | 8.70 |
| CHEMBL427845 | — | — | 1 | 8.66 |
| CHEMBL396981 | — | — | 1 | 8.57 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.55 |
| CHEMBL232660 | — | — | 1 | 8.52 |
| CHEMBL395022 | — | — | 1 | 8.48 |
| CHEMBL233053 | — | — | 1 | 8.32 |
| CHEMBL242820 | — | — | 1 | 8.28 |
| CHEMBL394801 | — | — | 1 | 8.28 |
| CHEMBL242817 | — | — | 1 | 8.24 |
| CHEMBL395096 | — | — | 1 | 8.24 |
| CHEMBL234525 | — | — | 1 | 8.20 |
| CHEMBL232661 | — | — | 1 | 8.12 |
| CHEMBL234732 | — | — | 1 | 8.10 |
| CHEMBL232218 | — | — | 1 | 8.08 |
| CHEMBL245130 | — | — | 1 | 8.00 |
| CHEMBL233470 | — | — | 1 | 8.00 |
| CHEMBL232620 | — | — | 1 | 7.82 |
| CHEMBL232621 | — | — | 1 | 7.82 |
| CHEMBL233681 | — | — | 1 | 7.72 |
| CHEMBL429440 | — | — | 1 | 7.68 |
| CHEMBL232010 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396945 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL234526 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL394787 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL394800 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL396459 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL233054 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL394861 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL233471 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL396703 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL427845 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL396981 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL41 | FLUOXETINE | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL232660 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL395022 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL233053 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL242820 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL394801 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL242817 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL395096 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL234525 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL232661 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL234732 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL232218 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL245130 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL233470 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL232620 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL232621 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL233681 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL429440 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL232010 | — | Ki | = | 25.0 | nM | 7.60 |